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Kishor K Bhakat Selected Research

DNA-(Apurinic or Apyrimidinic Site) Lyase (AP Endonuclease)

1/2022The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulates KRAS expression in pancreatic ductal adenocarcinoma cells.
4/2021APE1 and SSRP1 is overexpressed in muscle invasive bladder cancer and associated with poor survival.
1/2013Dual regulatory roles of human AP-endonuclease (APE1/Ref-1) in CDKN1A/p21 expression.
3/2008Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage.

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Kishor K Bhakat Research Topics

Disease

14Neoplasms (Cancer)
01/2022 - 08/2002
2Medulloblastoma
11/2021 - 01/2018
2Colorectal Neoplasms (Colorectal Cancer)
01/2020 - 03/2008
1Adenocarcinoma
01/2022
1Colonic Neoplasms (Colon Cancer)
01/2020
1Neoplasm Metastasis (Metastasis)
01/2018
1Carcinogenesis
04/2016
1Nervous System Heredodegenerative Disorders
04/2012
1Acute-Phase Reaction
02/2010
1Inflammation (Inflammations)
02/2010
1Pancreatic Neoplasms (Pancreatic Cancer)
10/2009
1Infections
06/2009
1Melanoma (Melanoma, Malignant)
10/2007
1Carcinoma (Carcinomatosis)
10/2005
1Glioma (Gliomas)
08/2002

Drug/Important Bio-Agent (IBA)

7Proteins (Proteins, Gene)FDA Link
04/2021 - 08/2002
4ChromatinIBA
01/2022 - 02/2010
4DNA-(Apurinic or Apyrimidinic Site) Lyase (AP Endonuclease)IBA
01/2022 - 03/2008
4DNA (Deoxyribonucleic Acid)IBA
04/2021 - 11/2003
3A-Form DNA (A-DNA)IBA
01/2022 - 11/2003
3Histone ChaperonesIBA
11/2021 - 01/2020
2Cisplatin (Platino)FDA LinkGeneric
11/2021 - 12/2008
2Protein Isoforms (Isoforms)IBA
04/2016 - 10/2007
2Pharmaceutical PreparationsIBA
03/2009 - 12/2008
2Messenger RNA (mRNA)IBA
03/2008 - 10/2005
2Temozolomide (Temodar)FDA LinkGeneric
10/2007 - 08/2002
1Carrier Proteins (Binding Protein)IBA
01/2022
1CBLC137IBA
11/2021
1Nucleosomes (Nucleosome)IBA
11/2021
1DNA Repair EnzymesIBA
11/2021
1EnzymesIBA
01/2020
1Fluorouracil (Carac)FDA LinkGeneric
01/2020
1Oncogene Proteins (Oncogene Protein)IBA
01/2018
1MetalsIBA
04/2012
1Interleukin-6 (Interleukin 6)IBA
02/2010
1EndonucleasesIBA
02/2010
1Transcription Factors (Transcription Factor)IBA
02/2010
1STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
02/2010
1GuanineIBA
10/2009
1Drug CombinationsIBA
10/2009
1Biological ProductsIBA
10/2009
1GemcitabineFDA Link
10/2009
1CalciumIBA
06/2009
1Co-Repressor ProteinsIBA
03/2009
1Doxorubicin (Adriamycin)FDA LinkGeneric
12/2008
1CamptothecinIBA
03/2008
1Topoisomerase I InhibitorsIBA
03/2008
1Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
10/2007
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
10/2007
1Peptides (Polypeptides)IBA
10/2005
1Glucose OxidaseIBA
10/2005
1Reactive Oxygen Species (Oxygen Radicals)IBA
10/2005
1Protein Kinases (Protein Kinase)IBA
11/2003
1NitrogenIBA
11/2003
1lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA
11/2003
1Phosphotransferases (Kinase)IBA
11/2003
1MethyltransferasesIBA
08/2003

Therapy/Procedure

4Drug Therapy (Chemotherapy)
01/2022 - 04/2016
3Therapeutics
01/2022 - 11/2003
1Aftercare (After-Treatment)
03/2008